- Recommendation basesd on reliable evidence --- this is the basic stance of Fujicco
- Two findings related to Equol
- Bone Health
- First in the world - confirmation of Bone Loss Preventing Effect by pure reagent
- Confirmation of the condition whereby: 'A person with high bone density has a high amount of urinary Isoflavones'
- By intake of Isoflavones, the urinary excretion of Bone Absorption Marker decreases
Restriction of Ca elution from bone was proven - Drinking Fujicco Tea containing Isoflavones proved the effect
- When exercise is added to intake of Isoflavones, Bone Density increases
- Walking combined with Fujiflavone intake prevents Bone Loss and reduces Body Fat
- More than 90mg Isoflavone intake increases Spine Bone Density of menopausal women
- Isoflavones promote Bone Formation
- Estrogen's Bone Mass Maintenance Mechanism made clear:
Important point of action is 'regulation of Osteoclasts life span'
- Menopausal Symptoms
- Occurrence of Hot Flashes among a group ingesting some amount of Isoflavones is less than half of that among a group taking a smaller amount
- Intake of Isoflavones prevents Atrophy of Mucosa and provides moisture
- Effect for Beautiful Skin confirmed:
Moisture maintenance・collagen creation・suppressing action against melanin
- Obesity
- Cardiovascular Diseases
- High Isoflavone Intake women group showed reduction of Cerebral and Myocardial Infarction Risk
- Isoflavone Intake lowers Blood Pressure
- Isoflavones reduce Serum Cholesterol
- Intake of 100mg Isoflavones lowers Serum Total Cholesterol and LDL Cholesterol
- A hypothesis of Isoflavones' Blood Pressure Reducing Mechanism was presented
- Cancers etc.
- Breast Cancer Mortality Rate is low in Soybean eating regions while in low Isoflavone Intake areas the mortality rate is high
- Isoflavones lower Breast Cancer Risk
- High Blood Isoflavone (Genistein) Level group shows lower Breast Cancer Incidence Rate
- Isoflavones prevent progress of Prostate Cancer
- Risk of Localized Prostate Cancer is lowered in higher Isoflavone Intake group
- High Soy Products intake group shows Mortality Rate Risk of Stomach Cancer reduced by half
- Isoflavones suppress Stress Induced Stomach Ulcer
TOPICS
Two findings related to Equol
1. Equol-producing bacterium was isolated from the human intestine
2. Equol production from glycitein was confirmed
From Fujicco's studies related to equol, the outlines of two most recent reports are presented:
Fujicco isolated an Equol-Producing Bacterium from the Human Intestine and proposed as the new genus and species, Adlercreutzia equolifaciens
It is becoming clearer that isoflavones show their strongest estrogen-like activity when they are metabolized to equol in human intestine.
According to one of our studies, an intervention test over one year of 'Walking combined with Fujiflavone intake' (refer to Bone Health), confirms the whole body bone density decreasing rate of equol-producing participants, who consisted of a half of participants, stayed at 1/3 of that of the non-producing participants.
The transform of isoflavones to equol was understood to be as a result of the activity of intestinal bacteria, but the specific bacterial strain has not been identified.
Fujicco in a joint research with RIKEN BioResource Center and the Japan National Institute of Health and Nutrition succeeded in detecting the equol-producing bacterium, Adlercreutzia equolifaciens in the human intestine by PCR method.
Equol-Production from Glycitein was confirmed
As for equol-production from isoflavones, many studies have been presented regarding daidzein's metabolism, but for glycitein's metabolism fewer studies have been reported.
In joint research with the University of Shizuoka, Fujicco confirmed that about 60% of glycitein was transformed to equol by SD rat gut microflora.
Glycitein is a substance contained mostly in soy hypocotyl as glycosides.
8th International Symposium on the Role of Soy in Health Promotion and Chronic Disease Prevention and Treatment; 2008
