Functions and Effects

Cancers etc.

Although breast cancer is considered to be caused by excessive action of the female hormone, why are isoflavones effective? About this question, several hypotheses are proposed.
One of them argues that isoflavones suppress the excessive action of estrogen.
Isoflavones have a binding affinity to estrogen receptor and the chemical structure is similar to that of the female hormone. It asserts that isoflavones approach the receptor in advance of strong estrogen to bind and suppress the strong action to prevent incidence of breast cancer or inhibit its progress. (This is confirmed by in vitro experiments).
Another argument is 'Angiogenesis Inhibiting Action'. It explains that cancer cells actively increase the blood vessels for their growth and intake of nutrition. But as isoflavones have the characteristic to suppress this angiogenesis, it restricts the growth of cancer cells and prevents their metastasizing.
Isoflavones are reported to be effective not only for hormone dependent cancers but also for other cancers.

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