- Recommendation basesd on reliable evidence --- this is the basic stance of Fujicco
- Two findings related to Equol
- Bone Health
- First in the world - confirmation of Bone Loss Preventing Effect by pure reagent
- Confirmation of the condition whereby: 'A person with high bone density has a high amount of urinary Isoflavones'
- By intake of Isoflavones, the urinary excretion of Bone Absorption Marker decreases
Restriction of Ca elution from bone was proven - Drinking Fujicco Tea containing Isoflavones proved the effect
- When exercise is added to intake of Isoflavones, Bone Density increases
- Walking combined with Fujiflavone intake prevents Bone Loss and reduces Body Fat
- More than 90mg Isoflavone intake increases Spine Bone Density of menopausal women
- Isoflavones promote Bone Formation
- Estrogen's Bone Mass Maintenance Mechanism made clear:
Important point of action is 'regulation of Osteoclasts life span'
- Menopausal Symptoms
- Occurrence of Hot Flashes among a group ingesting some amount of Isoflavones is less than half of that among a group taking a smaller amount
- Intake of Isoflavones prevents Atrophy of Mucosa and provides moisture
- Effect for Beautiful Skin confirmed:
Moisture maintenance・collagen creation・suppressing action against melanin
- Obesity
- Cardiovascular Diseases
- High Isoflavone Intake women group showed reduction of Cerebral and Myocardial Infarction Risk
- Isoflavone Intake lowers Blood Pressure
- Isoflavones reduce Serum Cholesterol
- Intake of 100mg Isoflavones lowers Serum Total Cholesterol and LDL Cholesterol
- A hypothesis of Isoflavones' Blood Pressure Reducing Mechanism was presented
- Cancers etc.
- Breast Cancer Mortality Rate is low in Soybean eating regions while in low Isoflavone Intake areas the mortality rate is high
- Isoflavones lower Breast Cancer Risk
- High Blood Isoflavone (Genistein) Level group shows lower Breast Cancer Incidence Rate
- Isoflavones prevent progress of Prostate Cancer
- Risk of Localized Prostate Cancer is lowered in higher Isoflavone Intake group
- High Soy Products intake group shows Mortality Rate Risk of Stomach Cancer reduced by half
- Isoflavones suppress Stress Induced Stomach Ulcer
Bone Health
Walking combined with Fujiflavone intake prevents Bone Loss and reduces Body Fat
Following the excellent results of the previously mentioned Animal Study, an Intervention Study, 'Walking exercise + Isoflavone intake', was carried out on women recruited through advertisement.
Fujicco and the National Institute of Health and Nutrition jointly performed a long term intervention study on women within 5 years after menopause.
The 136 women were formed into 4 groups, BMD and various body compositions were measured before the start of the trial and at 3, 6 and 12 months after the start.
The 4 groups were ①Placebo group, ②Isoflavone (Fujiflavone P40 capsule 47mg/day) group, ③Exercise group (Walking 45 minutes 3 times a week) and ④Isoflavone+Exercise group. The participants ingested isoflavone total 76mg every day including dietary isoflavones.
The results of the measurements by DXA method at the end of the year one trial revealed a great effect on bone density at the most vulnerable region for breakage, femoral Ward's triangle, while the Placebo group showed a decline. Nearly a 5% increase was observed in the combined group ④ and maintenance of the level in the Isoflavone group ② and Exercise group ③.
According to the body composition study conducted at the same time, it was proven that the Isoflavone plus exercise had significant restricting effect on the change rate of trunk fat mass which contain much visceral fat to which metabolic syndrome is attributed.
As for the comparison results of the whole body bone density change rates of the equol-producing participants which numbered approximately half of them, and the non-producing participants the change rate (decrease) of the equol-producing participants of isoflavone intake group was restrained to be about one third of that of the non-producing ones. The placebo group did not show much difference from the equol-producing ones and the non-producing.
JOURNAL OF BONE AND MINERAL RESEARCH Vol.21, No.5, 2006
